Product Description: Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride is also a lysosome inhibitor[1][2][3].
Applications: COVID-19-anti-virus
Formula: NH4Cl
Citations: Acta Pharm Sin B. 2021 Mar 11./Antiviral Res. 2023 Apr 17;105606./Aquaculture. 2025 Feb 15./Biochem Pharmacol. 2018 Apr;150:280-292./Cell Death Dis. 2024 Sep 11;15(9):665./iScience. 2024 Mar 9./Nat Commun. 2024 Jul 18;15(1):6043./Nat Commun. 2025 Jan 2;16(1):339./PLoS Pathog. 2024 Feb 14;20(2):e1011981./Research Square Preprint. 2023 Jun 22./Signal Transduct Target Ther. 2024 Dec 30;9(1):367./Virol J. 2022 Sep 20;19(1):151./Viruses. 2019 Dec 30;12(1):43./bioRxiv. 2024 November 19.
References: [1]Huang X, et al. NH4Cl treatment prevents doxorubicin-induced myocardial dysfunction in vivo. Life Sci. 2019;227:94-100. /[2]Canning WM, Fields BN. Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells. Science. 1983;219(4587):987-988. /[3]Yu C,et al. Lysosome dysfunction enhances oxidative stress-induced apoptosis through ubiquitinated protein accumulation in Hela cells. Anat Rec (Hoboken). 2013 Jan;296(1):31-9.
CAS Number: 12125-02-9
Molecular Weight: 53.49
Compound Purity: 99.67
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)
Target: Autophagy
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