Product Description: Ammonium chloride, for cell culture (Salmiac, for cell culture) is a reagent that can be used in cell culture to provide a source of nitrogen. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.Ammonium chloride is also a lysosome inhibitor.
Formula: NH4Cl
Citations: bioRxiv. 2024 November 19./Acta Pharm Sin B. 2021 Mar 11./Antiviral Res. 2023 Apr 17;105606./Aquaculture. 2025 Feb 15./Biochem Pharmacol. 2018 Apr;150:280-292./Cell Death Dis. 2024 Sep 11;15(9):665./iScience. 2024 Mar 9./Nat Commun. 2024 Jul 18;15(1):6043./Nat Commun. 2025 Jan 2;16(1):339./PLoS Pathog. 2024 Feb 14;20(2):e1011981./Research Square Preprint. 2023 Jun 22./Signal Transduct Target Ther. 2024 Dec 30;9(1):367./Virol J. 2022 Sep 20;19(1):151./Viruses. 2019 Dec 30;12(1):43.
References: [1]Yu C,et al. Lysosome dysfunction enhances oxidative stress-induced apoptosis through ubiquitinated protein accumulation in Hela cells. Anat Rec (Hoboken). 2013 Jan;296(1):31-9. /[2]Huang X, et al. NH4Cl treatment prevents doxorubicin-induced myocardial dysfunction in vivo. Life Sci. 2019;227:94-100./[3]Canning WM, Fields BN. Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells. Science. 1983;219(4587):987-988.
CAS Number: 12125-02-9
Molecular Weight: 53.49
Compound Purity: 99.0
Research Area: Cancer
Solubility: H2O : ≥ 100 mg/mL
Target: Autophagy;Biochemical Assay Reagents
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