Product Description: Dextran T3 (Dextran 3; Dextran T3(MW 2400-3600)) is a neural tracer and intestinal permeability probe that can move anterogradely and retrogradely in neuronal axons by passive diffusion. Dextran T3 (MW 3,000) is able to permeate across the intestinal epithelial cell membrane in the presence of cholera toxin-induced cytoskeletal disturbance. Dextran T3 (MW 3,000) is used as a fluorescent marker to rapidly label developing neurons (such as Xenopus retinal ganglion cells) and to assess intestinal barrier function. It can be used to study axonal transport in neuroanatomy and permeability changes in intestinal pathophysiology.
Formula: (C6H10O5)n
References: [1]Chen F, et al. Preparation and application of dextran and its derivatives as carriers. Int J Biol Macromol. 2020 Feb 15;145:827-834./[2]Fritzsch B. Fast axonal diffusion of 3000 molecular weight dextran amines. J Neurosci Methods. 1993 Oct;50(1):95-103./[3]Magnusson K E, et al. Effect of cholera toxin on rat intestinal permeability assessed with fluorescent dextran 3000[J]. FEMS microbiology letters, 1985, 29(1-2): 15-18.
CAS Number: 9004-54-0
Molecular Weight: 2400-3600
Research Area: Others
Solubility: H2O : ≥ 100 mg/mL
Target: Biochemical Assay Reagents
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