Product Description: LGD-2226 is a selective and orally active androgen receptor modulator with an EC50 of 0.2 nM and a Ki of 1.5 nM for human androgen receptor. LGD-2226 shows tissue selectivity in animal models, with reduced effects on prostate compared to muscle. LGD-2226 can be used for muscle wasting, osteoporosis and sexual dysfunction[1][2].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C14H9F9N2O
References: [1]van Oeveren A, et al. Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. J Med Chem. 2006 Oct 19;49(21):6143-6./[2]Miner JN, et al. An orally active selective androgen receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate. Endocrinology. 2007 Jan;148(1):363-73.
CAS Number: 328947-93-9
Molecular Weight: 392.22
Compound Purity: 98.58
Research Area: Endocrinology; Metabolic Disease
Solubility: DMSO : 125 mg/mL (ultrasonic)
Target: Androgen Receptor
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