Product Description: Lipopolysaccharides, from Akkermansia muciniphila (LPS, from Akkermansia muciniphila) are lipopolysaccharide endotoxins derived from Akkermansia muciniphila and are TLR-4 activators. Unlike typical LPS, Lipopolysaccharides, from Akkermansia muciniphila are R-type LPS or lipooligosaccharides (LOS), lacking the O-antigen domain and consisting only of a core oligosaccharide and a lipid A. Lipopolysaccharides, from Akkermansia muciniphila can activate TLR4 and TLR2, and may inhibit the TLR4/NF-κB pathway, thereby alleviating LPS-induced acute kidney injury[1][2].
Formula: N/A
References: [1]Garcia-Vello P, et al. The lipooligosaccharide of the gut symbiont Akkermansia muciniphila exhibits a remarkable structure and TLR signaling capacity. Nat Commun. 2024 Sep 27;15(1):8411./[2]Shi J, et al. Akkermansia muciniphila attenuates LPS-induced acute kidney injury by inhibiting TLR4/NF-κB pathway. FEMS Microbiol Lett. 2022 Nov 17;369(1):fnac103.
Molecular Weight: N/A
Research Area: Others
Target: Biochemical Assay Reagents
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