Product Description: Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy[1][2][3].
Applications: COVID-19-immunoregulation
Formula: C6H11NO2
References: [1]He M, et al. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33(6):401-7./[2]Plecko B, et, al. Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. Neuropediatrics. 2005 Jun;36(3):200-5./[3]Liying Luo, et al. "Pipecolic acid mitigates ferroptosis in diabetic retinopathy by regulating GPX4-YAP signaling." Biomedicine & Pharmacotherapy 169 (2023): 115895.
CAS Number: 535-75-1
Molecular Weight: 129.16
Compound Purity: 98.0
Research Area: Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility: H2O : 50 mg/mL (ultrasonic)
Target: Endogenous Metabolite;Ferroptosis;Glutathione Peroxidase;YAP
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