Product Description: Sodium iodoacetate is a specific inhibitor of GAPDH and has glycolysis inhibitory activity. In addition, sodium iodoacetate can induce osteoarthritis and related pain models in experimental animals[1][2][3][4].
Formula: C2H2INaO2
References: [1]Xu, Y. et al. Glycolysis in Innate Immune Cells Contributes to Autoimmunity. Frontiers in Immunology, 13. /[2]Na, H. et al. Soluble CCR2 gene therapy controls joint inflammation, cartilage damage, and the progression of osteoarthritis by targeting MCP-1 in a monosodium iodoacetate (MIA)-induced OA rat model. Journal of Translational Medicine, 20(1)/[3]Kobayashi K, et al. Sodium iodoacetate-induced experimental osteoarthritis and associated pain model in rats[J]. Journal of Veterinary Medical Science, 2003, 65(11): 1195-1199./[4]Güler N, et al. Sodium iodoacetate induced osteoarthrosis model in rabbit temporomandibular joint: CT and histological study (part I)[J]. International journal of oral and maxillofacial surgery, 2011, 40(11): 1289-1295.
CAS Number: 305-53-3
Molecular Weight: 207.93
Compound Purity: 99.91
Research Area: Metabolic Disease; Inflammation/Immunology
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : ≥ 100 mg/mL
Target: Biochemical Assay Reagents
English
Deutsch
