Product Description: Tris(3-hydroxypropyltriazolylmethyl)amine (THPTA) is an accelerating ligand in the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) and protects cells from oxidants generated by copper-catalyzed reduction of oxygen by ascorbate. In addition, Tris(3-hydroxypropyltriazolylmethyl)amine can also protect the histidine moiety of biomolecules in a manner proportional to the ligand concentration[1][2][3][4][5].
Formula: C18H30N10O3
References: [1]Hong V, et al. Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation. Angew Chem Int Ed Engl. 2009;48(52):9879-83./[2]Hong V, et al. Labeling live cells by copper-catalyzed alkyne− azide click chemistry. Bioconjugate chemistry 21.10 (2010): 1912-1916./[3]Rathinam S, et al. Conjugation of CRAMP18-35 Peptide to Chitosan and Hydroxypropyl Chitosan via Copper-Catalyzed Azide-Alkyne Cycloaddition and Investigation of Antibacterial Activity. Int J Mol Sci. 2024 Aug 30;25(17):9440./[4]Yuan Y, et al. Bioorthogonal Turn-On Probe Based on Aggregation-Induced Emission Characteristics for Cancer Cell Imaging and Ablation. Angew Chem Int Ed Engl. 2016 May 23;55(22):6457-61./[5]Kozarski M, et al. Towards superior mRNA caps accessible by click chemistry: synthesis and translational properties of triazole-bearing oligonucleotide cap analogs. RSC Adv. 2023 Apr 25;13(19):12809-12824.
CAS Number: 760952-88-3
Molecular Weight: 434.50
Compound Purity: 99.54
Research Area: Others
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : ≥ 175 mg/mL
Target: Biochemical Assay Reagents
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