Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-deoxy-D-arabino-hexose
Purity: ≥98%
Formula Markup: C6H12O5
Formula Weight: 164.2
CAS Number: 154-17-6
Notes: 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.{22664,61618} It is metabolized by hexokinase into 2-deoxy-D-glucose-6-phosphate (2-DG6P), which cannot be metabolized by glucose-6-phosphate isomerase, leading to 2-DG6P accumulation, inhibition of glycolysis, and cell death.{72381} 2-deoxy-D-glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml.{61619,22663} In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin (Item No. 15007) or paclitaxel (Item No. 10461).{61620}
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