Formulation: A solid
Formal Name: 1,2:5,6-dianhydro-galactitol
Purity: ≥95%
Formula Markup: C6H10O4
Formula Weight: 146,1
Shelf life (days): 1460
CAS Number: 23261-20-3
Notes: Dianhydrogalactitol is a hexitol epoxide DNA alkylating agent that has been found in P. caesiopruinosa.{67347,67348} It induces N7-alkylation of guanine and interstrand DNA cross-links in vitro.{67347} Dianhydrogalactitol (0.5-8 µM) halts the cell cycle at the G2/M phase in U-251MG and T98G glioblastoma cells.{67349} It decreases the migration and invasion of U251 glioblastoma cells and tube formation of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 12.5 µg/ml.{67350} Dianhydrogalactitol (2.5 mg/kg) increases survival in a U-251MG mouse xenograft model when administered in combination with the alkylating agent prodrug temozolomide (Item No. 14163).{67349}
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