Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (S)-2-amino-N-(4-(((S)-2-Mamino-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamido)methyl)benzyl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide, monoacetic acid
Purity: ≥98%
Formula Markup: C46H68N10O8S2 / C2H4O2
Formula Weight: 1013.284
Notes: A peptidomimetic antibiotic agent; forms self-aggregates in the presence of dsDNA (CAC = 8 µg/ml); selectively induces intracellular aggregation in B. subtilis over HEK293T cells at 128 µg/ml; active against S. aureus, MRSA, B. subtilis, E. faecium, and M. smegmatis (MICs = 8, 4, 4, 8, and 16 µg/ml, respectively); not cytotoxic to NIH3T3 or HK-2 cells (IC50s = >256 µg/ml for both); extended exposure of S. aureus or E. coli to dAPM-1 for greater than 40 and 30 days, respectively, does not induce resistance to dAPM-1; increases survival in a mouse model of S. aureus-induced sepsis at 10 mg/kg
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