Shelf life (days): 1460
Info: An anticancer agent; intercalates into DNA and inhibits topoisomerase II; inhibits mitochondrial complex IV, also known as cytochrome c oxidase (IC50 = 70 µM for the potato enzyme); inhibits the growth of L1210 leukemia cells (IC50 = 0.076 µM); cytotoxic to primary human hepatocytes (IC50 = 4 µM); reduces glycogen synthesis, albumin synthesis, total protein synthesis, gluconeogenesis, triglyceride secretion, and ureogenesis in isolated rat hepatocytes (IC50s = 14.3, 15.4, 3, 28.8, 2.3, and 96.4 µM, respectively); increases survival in several murine models of cancer
Formulation: A solid
Formal Name: 2-[2-(diethylamino)ethyl]-9-hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazolium, monochloride, monohydrochloride
Purity: ≥98%
Formula Markup: C23H28N3O • Cl [HCl]
Formula Weight: 434.405
CAS Number: 157000-76-5
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