Shelf life (days): 180.0
Formulation: 50 mM Potassium phosphate pH 7.6, with 5% glycerol, 50 mM sodium chloride, 1 mM EDTA, and 0.1 mM DTT
Uniprot ID: P28845
Purity: ≥40% estimated by SDS-PAGE
Formula Weight: 0.0
Notes: 11β-Hydroxysteroid dehydrogenase (11β-HSD) exists as two isozymes 11β-HSD1 and 11β-HSD2.{18526} Both isoforms are members of the short-chain dehydrogenase/reductase (SDRs) family.{18527} 11β-HSD1 is a membrane-bound glycoprotein localized on the endoplasmic reticulum. The main catalytic domain of 11β-HSD1 lies within the lumen of the ER. A short five amino acid N-terminal region extends into the cytoplasm and is linked to the catalytic portion through a single transmembrane helix.{18526} 11β-HSD1 is a relatively low affinity NADP-dependent enzyme with a bidirectional catalytic activity. The dehydrogenase reductase activity of 11β-HSD1 catalyzes the conversion of cortisol to cortisone. The primary function of 11β-HSD1 is the oxoreduction of cortisone to the active glucocorticoid cortisol.{18527} Cortisol is a steroid hormone essential for a variety of physiological and homeostatic functions.
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