Formulation: A solid
Formal Name: N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-3-pyridazinecarboxamide
Purity: ≥98%
Formula Markup: C41H43ClFN9O6
Formula Weight: 812,3
Shelf life (days): 1460
CAS Number: 2222112-77-6
Notes: ARV-110 is a proteolysis-targeting chimera (PROTAC) that contains a cereblon ligand 1-derivative connected to an androgen receptor (AR) ligand by a linker region.{51525} It reduces AR levels in VCaP prostate cancer cells in a time- and concentration-dependent manner. ARV-110 (1 µM) decreases VCaP cancer cell proliferation. In vivo, ARV-110 reduces tumor volume in a VCaP prostate cancer xenograft model that is resistant to the non-steroidal AR antagonist enzalutamide (MDV 3100; Item No. 11596).
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