Product Description: Cholesterol oxidase, Rhodococcus sp. is a key enzyme in the cholesterol degradation process. It catalyzes the isomerization and oxidation of cholesterol mediated by the coenzyme FAD. Research indicates that cholesterol oxidase plays a crucial role in the pathogenicity of Mycobacterium tuberculosis by modulating the host macrophage immune response through inhibition of the Toll-like receptor 2 (TLR2) signaling pathway, thereby enhancing the survival of Mycobacterium tuberculosis. Cholesterol oxidase, from Rhodococcus sp., shows potential for research in the field of tuberculosis[1][2].
Formula: N/A
References: [1]Cui H, et al. Heterologous Expression and Function of Cholesterol Oxidase: A Review. Protein Pept Lett. 2023;30(7):531-540./[2]Brzostek A, et al. Cholesterol oxidase is required for virulence of Mycobacterium tuberculosis. FEMS Microbiol Lett. 2007 Oct;275(1):106-12.
CAS Number: 9028-76-6
Molecular Weight: N/A
Research Area: Infection; Metabolic Disease
Target: Toll-like Receptor (TLR)
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