Shelf life (days): 180.0
Formulation: 50 mM Tris pH 7.5, 150 mM sodium chloride
Uniprot ID: P14174
Purity: ≥95% estimated by SDS-PAGE
Formula Weight: 0.0
Notes: Macrophage Migration Inhibitory Factor (MIF) is a small, pro-inflammatory cytokine. MIF signaling is important in septic shock, arthritis, colitis, and cardiovascular diseases.{24687} MIF counteracts glucocorticoid signaling, which would otherwise inhibit inflammation. Secreted MIF binds to CD74 receptors, which then couple to CD44, during monocyte recruitment.{24685} In addition to CD44 binding, MIF is an enzymatically active keto-enol tautomerase that is inhibited by isothiocyanates such as sulforaphane.{24684} Overexpression of MIF has been seen in several cancers. MIF overexpression has been shown to promote hypoxia induced HIF-1α stabilization leading to changes in the tumor microenvironment, including stimulation of angiogenesis and neovascularization.{24686}
English
Deutsch
