Thioredoxin Glutathione Reductase (Schistosoma mansoni, reco

Thioredoxin Glutathione Reductase (Schistosoma mansoni, reco
SKU
CAY39632-250
Packaging Unit
250 µg
Manufacturer
Cayman Chemical

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Shelf life (days): 365.0

Formulation: TE buffer with 50% glycerol

Purity: ≥95% estimated by SDS-PAGE

Formula Weight: 0.0

Notes: Thioredoxin glutathione reductase (TGR) is a selenocysteine-containing oxidoreductase flavoenzyme that protects Schistosoma, the genus of blood flukes that causes schistosomiasis, and other helminth parasites from host-induced oxidative damage.{72051,72052} It is a homodimer that contains an N-terminal glutathione reductase domain, an FAD- and NADPH- binding site, and a thioredoxin domain near the C-terminus, and it can reduce both DTNB and oxidized glutathione (GSSH).{72052} TGR catalyzes NADPH- and FAD-dependent reduction of oxidized thioredoxin (Trx), glutathione (GSH), and glutaredoxin (Grx), which mitigate the effects of reactive oxygen and nitrogen species released by host neutrophils and macrophages that can damage intracellular proteins and lipids.{72053} Cayman's TGR (Schistosoma mansoni, recombinant) protein can be used for enzyme activity assays.
More Information
SKU CAY39632-250
Manufacturer Cayman Chemical
Manufacturer SKU 39632-250
Package Unit 250 µg
Quantity Unit STK
Clonality Recombinant
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