Thioredoxin Reductase 1 (C. elegans, recombinant)

Formulation: TE buffer with 50% gylcerol

Purity: ≥95% estimated by SDS-PAGE

Shelf life (days): 365

Notes: Thioredoxin reductase 1 (TrxR1) is a selenocysteine-containing oxidoreductase and the only selenoprotein in C. elegans.{68493} It contains a dimerization domain, FAD- and NADPH-binding domains, an N-terminal redox catalytic site, and a C-terminal selenocysteine residue, which is essential for the catalytic activity of TrxR1. TrxR1 is expressed in the hypodermis, pharynx, vulva, intestine, and nervous system and localizes to the cytoplasm in C. elegans.{68493,52832} Knockout of trxr1 sensitizes C. elegans to oxidative stress in a context-dependent manner and does not affect C. elegans lifespan, brood size, or molting.{68494,68493} However, double knockout of trxr1 and the gene encoding glutathione reductase (gsr1) induces arrest at the molting stage, an effect that can be rescued by exogenous glutathione (GSH).{68493} Increased serum TrxR1 activity is associated with reduced progression-free survival in patients with non-small cell lung cancer (NSCLC).{52835} Cayman's Thioredoxin Reductase 1 (C. elegans, recombinant) protein can be used for enzyme activity assays.

• SKU: CAY39628-200
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39628-200
• Green Labware: No
• Package Unit: 200 µg
• Quantity Unit: STK
• Application: Enzyme Activity