Formulation: TE buffer with 50% glycerol
Purity: ≥95% estimated by SDS-PAGE
Shelf life (days): 365
Notes: Thioredoxin reductase 2 (TrxR2) is an oxidoreductase encoded by the TXNRD2 gene in humans and a member of the antioxidant thioredoxin system.{14257} It exists as a homodimer and contains a dimer interface domain, FAD- and NADPH-binding domains, an N-terminal redox catalytic site, and a C-terminal selenocysteine residue, which is essential for the catalytic activity of TrxR2.{14257,65805} TrxR2 is ubiquitously expressed and localizes primarily to the mitochondria.{52832} It catalyzes the NADPH-dependent reduction of oxidized thioredoxin 2 (Trx2), restoring the disulfide reductase function of Trx2, which reduces peroxiredoxin-3 (Prx3) dimers.{52833,57136} TrxR2 has roles in the maintenance of mitochondrial integrity and redox homeostasis in the aging heart and in the regulation of chondrocyte viability, proliferation, and differentiation.{65805} Genome-wide deletion of Txnrd2 is embryonic lethal in mice.{65806} TXNRD2 expression and TrxR2 protein levels are increased in bone biopsies from patients with osteosarcoma that later progress to metastatic disease.{65807} SNPs in TXNRD2 are associated with serum markers of selenium status in patients with advanced- or high-stage, but not localized low-grade, prostate cancer.{65808} Cayman’s Thioredoxin Reductase 2 (human, recombinant) protein can be used for enzyme activity assays.
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