VZ 185, CAS 2306193-61-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (2S,4R)-N-(2-((5-(4-(2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide

Purity: ≥98%

Formula Markup: C53H67FN8O8S

Formula Weight: 995.212603

CAS Number: 2306193-61-1

Notes: A PROTAC that drives BRD7 and BRD9 degradation; selective for BRD7 and BRD9 over 6,273 other proteins at 100 nM; degrades BRD7 and BRD9 in a cell-free assay (DC50 = 4.5 and 1.8 nM, respectively); decreases BRD7 and BRD9 levels in HeLa cells by 10 and 14%, respectively, at 1 µM; reduces the proliferation of EoL-1 and A-204 cells (IC50s = 3.4 and 39 nM, respectively)

• SKU: CAY41454-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41454-5
• Package Unit: 5 mg
• Quantity Unit: STK