Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 6-[6-[2-(2-hydroxyethoxy)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)amino]-3H-imidazo[4,5-b]pyridin-3-yl]-3-pyridinecarbonitrile
Purity: ≥98%
Formula Markup: C21H24N6O4
Formula Weight: 424.4533
CAS Number: 2095615-97-5
Notes: An IRAK4 inhibitor (IC50s = 6.4 and 3.5 nM for the human and mouse enzymes, respectively); selective for IRAK4 over IRAK1 (IC50 = 179 nM) and a panel of 151 additional kinases at 1 µM but does inhibit FLT3, TrkB, and VEGFR3 (IC50s = 2.2, 5.8, and 57 nM, respectively); inhibits CL097-induced TNF-α release in isolated human PBMCs and human whole blood (IC50s = 122.8 and 568 nM, respectively); reduces ear thickness in mouse models of psoriasis induced by recombinant mouse IL-23 or imiquimod and mouse models of atopic dermatitis induced by recombinant mouse IL-33 or MC903
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