Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N2,N6-bis[2-[(1,1-dimethylethyl)thio]ethyl]-2,6-pyridinedicarbothioamide
Purity: ≥98%
Formula Markup: C19H31N3S4
Formula Weight: 429.718
CAS Number: 1009838-93-0
Notes: An antifibrotic compound and AMPK activator; inhibits TGF-β1-induced collagen, fibronectin 1, and CTGF production in primary human dermal fibroblasts at 3 µM; increases AMPK activation, glucose uptake, and membrane translocation of Glut4 in L6 rat myocytes expressing the human transporter at 10 µM; inhibits glucose-induced triglyceride production in HepG2 cells at 50 µM; reduces blood glucose levels, increases AMPK activation, and suppresses hepatic fibrosis and lipid accumulation in mice fed a high-fat diet at 10 mg/kg; decreases dermal thickness and inflammatory cell infiltration in a mouse model of bleomycin-induced fibrosis
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