A-582941, CAS 848591-90-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole, dihydrochloride

Purity: ≥98%

Formula Markup: C17H20N4 / 2HCl

Formula Weight: 353.28894

CAS Number: 848591-90-2

Notes: An agonist of a7 nAChRs; induces inward currents in Xenopus oocytes expressing the rat or human receptor (EC50s = 2.45 and 4.26 µM, respectively), which can be reversed by methyllycaconitine; selectively binds to a7 nAChRs (Kis = 10.8 and 16.7 nM for the rat and human receptors, respectively) over a panel of >75 receptors and ion channels, including muscarinic receptors, at 10 µM but does bind to 5-HT3 (Ki = 154 nM); improves cognitive deficits in the 3xTg transgenic mouse model of Alzheimer’s disease at 12 mg/kg; increases accuracy in the DMTS test in rhesus monkeys at 10 mg/kg

• SKU: CAY42375-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42375-100
• Package Unit: 100 mg
• Quantity Unit: STK