Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[1-[[(cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxy-benzeneacetamide
Purity: ≥98%
Formula Markup: C26H30N6O3
Formula Weight: 474.6
CAS Number: 861393-28-4
Notes: A-740003 is a competitive antagonist of the ATP-gated ionotropic P2X7 receptor (IC50s = 40 and 18 nM for human and rat receptors, respectively).{33388} It shows weak or no activity at other P2 receptors and other receptors and ion channels. A-740003 blocks agonist-induced IL-1β release and pore formation in differentiated THP-1 cells (IC50s = 156 and 92 nM, respectively).{33388} It is effective in vivo when administered intraperitoneally, reducing pain in several animal models.{33388} A-740003 is used in cell and animal studies to elucidate P2X7 roles and signaling pathways.{22913,33386,33387}
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