Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine, monohydrochloride
Purity: ≥98%
Formula Markup: C9H10Cl2N4 / HCl
Formula Weight: 281.6
CAS Number: 73218-79-8
Notes: Apraclonidine is an α2-adrenergic receptor (α2-AR) agonist and structural analog of clonidine (Item No. 15949).{40474} It binds to α2-ARs in calf cortex, rat kidney, and rat spleen with IC50 values of 0.9, 4.3, and 4.2 nM, respectively. Apraclonidine also binds to α2-ARs in rat cerebral cortex, pig submandibular gland and lung tissue, and in dog kidney membrane (Kds = 0.87, 5.28, 1.30, and 5.25 nM, respectively).{40475,40476} It inhibits noradrenaline-stimulated contraction in guinea pig ileum and rabbit vas deferens (EC50s = 7.59 and 6.76 nM, respectively).{40477} Opthalmic formulations containing apraclonidine have been used to treat elevated intraocular pressure.
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