Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-amino-6-chloro-2-methyl-N-[[1-(2-methylpropyl)-4-piperidinyl]methyl]-imidazo[1,2-a]pyridine-8-carboxamide
Purity: ≥98%
Formula Markup: C19H28ClN5O
Formula Weight: 377.91142
CAS Number: 519148-48-2
Notes: A 5-HT4 receptor partial agonist; induces cAMP accumulation in HEK293 cells expressing human 5-HT4D receptors and relaxation of rat tunica muscularis mucosae strips (EC50s = 0.927 and 1.3 nM, respectively); selectively binds to 5-HT4D over 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, and 5-HT2B receptors (Kis = 1.26, >4,820, >5,070, 2,150, 1,400, and 2,900 nM, respectively) and 5-HT3, 5-HT7, and dopamine D2 receptors (Kis = 4,590, >3,890, and 2,150 nM, respectively), as well as a panel of >50 additional receptors at 1,000 nM; increases gastric antral motility in conscious dogs in the fasted or postprandial states at 0.3 mg/kg; reverses clonidine-induced decreases in gastric emptying in a dog model of gastroparesis; induces superoxide production in a light-dependent manner and is phototoxic to NIH3T3 fibroblasts (IC50s = 11.4 and 203.3 µg/ml in the presence and absence of light, respectively)
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