Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[5-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)-2-pyrazinyl]-2-fluoro-6-methyl-benzamide
Purity: ≥98%
Formula Markup: C19H11ClF3N3O3
Formula Weight: 421.8
CAS Number: 1713240-67-5
Notes: An inhibitor of Orai1/STIM1-containing SOCs (IC50 = 120 nM); selective for Orai1/STIM1-containing SOCs over Orai2/STIM2-containing SOCs (IC50 = 900 nM); decreases cholecystokinin- or taurolithocholic acid 3-sulfate-induced cell death in isolated mouse, rat, and human acini at 3 µM; reduces blood amylase and lipase levels and pancreatic trypsin activity in a mouse model of cerulein-induced acute pancreatitis at 20 mg/kg