Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol
Purity: ≥98% (mixture of isomers)
Formula Markup: C26H29NO2
Formula Weight: 387.514
CAS Number: 165813-01-4
Notes: (E/Z)-Droloxifene is a mixture of (E)-droloxifene, a selective estrogen receptor modulator (SERM), and (Z)-droloxifene.{54810} (E)-Droloxifene binds to the estrogen receptor (ER) in rabbit uterine homogenates (IC50 = 24 nM in a radioligand binding assay), increases uterine weight in immature rats, and reduces estradiol-induced increases in uterine weight in juvenile rats.{54810,54811,72329} It also inhibits 17β-estradiol-stimulated growth of MCF-7, ZR-75-1, and T47D human breast cancer cells in a concentration-dependent manner.{54813} (Z)-Droloxifene binds weakly to ERs and has no estrogenic or antiestrogenic activity.{72328}
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