Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl-3,3,4,4,4-d5]-phenol
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C26H24D5NO2
Formula Weight: 392.6
CAS Number: 2470232-57-4
Notes: (E/Z)-4-hydroxy Tamoxifen-d5 is intended for use as an internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen (Item No. 17308) by GC- or LC-MS. (E/Z)-4-hydroxy Tamoxifen is a mixture of (E)-4-hydroxy tamoxifen and (Z)-4-hydroxy tamoxifen.{28446} (Z)-4-hydroxy Tamoxifen is an active metabolite of the estrogen receptor antagonist tamoxifen (Item Nos. 13258 / 11629) and is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (Z)-4-hydroxy Tamoxifen (100 nM) inhibits 17β-estradiol-induced increases in the mRNA encoding progesterone receptor in MCF-7 breast cancer cells.{67256} (Z)-4-hydroxy Tamoxifen inhibits the proliferation of MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively).{28444}
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