Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-benzeneacetic acid, monohydrochloride
Purity: ≥98%
Formula Markup: C33H31ClF3NO3 / HCl
Formula Weight: 618.5
CAS Number: 405911-17-3
Notes: The liver X receptors, LXRα and LXRβ, are nuclear receptors that act as ligand-dependent transcription factors.{24819} They modulate cholesterol, fatty acids, and glucose homeostasis. GW 3965 is an orally-active agonist of LXRα and LXRβ, activating the human isoforms with EC50 values of 190 and 30 nM, respectively.{10881} It alters LXR-regulated gene expression in mice and rats, affecting pathways related to glucose and lipid metabolism.{10881,24822,24821} GW 3965 also affects inflammation and pressor responses through LXRα and LXRβ.{10880,24823,24820}
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