GW 542573X, CAS 660846-41-3

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 4-[[[[(2-methoxyphenyl)amino]carbonyl]oxy]methyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester

Purity: ≥98%

Formula Markup: C19H28N2O5

Formula Weight: 364.442

CAS Number: 660846-41-3

Notes: A KCa2.1/SK1 activator; increases current in an inside-out patch clamp assay using HEK293 cells expressing the human channel (EC50 = 8.2 µM); selective for KCa2.1/SK1 over KCa2.2/SK2, KCa2.3/SK3, and KCa3.1/IK in whole-cell patch clamp assays using HEK293 cells expressing the human channels at 10 µM, as well as Nav1.3, Cav2.2, and Kv1.3 and the purinergic P2X2/3 receptor and α7 nAChR at 30 µM; decreases freezing time in contextual fear but not cued fear memory tests in mice when administered prior to the conditioning period at 15 mg/kg

• SKU: CAY43213-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 43213-1
• Package Unit: 1 mg
• Quantity Unit: STK