JKC363 (acetate)

Shelf life (days): 1460

Info: An MC4R antagonist (IC50 = 0.5 nM); selective for MC4R over MC3R (IC50 = 44.9 nM); decreases basal and α-MSH- or γ2-MSH-induced TRH secretion in rat hypothalamic explants at 100 nM; inhibits [Nle4,D-Phe7]-α-MSH induced proliferation of isolated postnatal rat hippocampal neural precursor cells at 10 nM; intrathecal administration decreases paw licking and flinching in the formalin test in mice at 5 nmol/animal

Formulation: A solid

Formal Name: cyclic (1→7)-disulfide N-(3-mercapto-1-oxopropyl)-L-α-glutamyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-L-α-asparagine, acetate

Amino Acids: cyclo(X1EHx2RWGC)PPKD-NH2 (X1=β-mercaptopropionate

Purity: ≥98%

Formula Markup: C69H91N19O16S2 • XC2H4O2

Formula Weight: 1506.7113

• SKU: CAY41555-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41555-5
• Package Unit: 5 mg
• Quantity Unit: STK