Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro-2H-3,1-benzoxazin-2-one
Purity: ≥95%
Formula Markup: C28H33N3O6
Formula Weight: 507.6
CAS Number: 162042-44-6
Notes: A nonpeptide oxytocin receptor antagonist (Ki = 19 and 4.6 nM for the rat uterine and human uterine receptors, respectively); selective for oxytocin receptors over human AVP receptors V1A and -V2 (Kis = 3,200 and >10,000 nM for the human platelet and kidney receptors, respectively) and rat AVP receptor V2 (Ki = >10,000 nM for the rat kidney receptor) but also inhibits rat AVP receptor V1A (Ki = 3.7 nM for the rat liver receptor); inhibits spontaneous contractions in isolated human myometrial strips (IC50 = 71 pM); inhibits oxytocin-induced uterine contractions in rats (ED50 = 0.55 mg/kg)
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