LY310762, CAS 192927-92-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-one, monohydrochloride

Purity: ≥98%

Formula Markup: C24H27FN2O2 / HCl

Formula Weight: 430.942503

CAS Number: 192927-92-7

Notes: LY310762 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT1D (Ki = 249 nM for guinea pig receptors).{40403} It is selective for 5-HT1D over the 5-HT1B receptor, where it inhibits binding of radiolabeled citalopram by only 32% when used at a concentration of 1,000 nM. LY310762 potentiates 5-HT (Item No. 14332) release stimulated by potassium in guinea pig cortex (EC50 = 31 nM). It also reverses vasodilation induced by 5-HT in rat kidney perfused by phenylephrine (Item Nos. 17205 / 18619) when administered at a dose of 1 mg/kg.{40402}

• SKU: CAY22938-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22938-5
• Package Unit: 5 mg
• Quantity Unit: STK