Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-oxo-L-prolylglycyl-L-cysteinyl-L-cysteinyl-L-asparaginylglycyl-L-prolyl-L-lysylglycyl-L-cysteinyl-L-seryl-L-seryl-L-lysyl-L-tryptophyl-L-cysteinyl-L-arginyl-L-a-aspartyl-L-histidyl-L-alanyl-L-arginyl-L-cysteinyl-L-cysteinamide, cyclic (3?15),(4?21),(10?22)-tris(disulfide), acetate
Purity: ≥98%
Formula Markup: C92H139N35O28S6 / XC2H4O2
Formula Weight: 2375.70316
Notes: A conotoxin and an inhibitor of Nav1.4 receptors; inhibits Nav1.4 in HEK293 cells (IC50 = 2.3 nM for the rat channel); inhibits rat Nav1.2 channels in HEK293 cells at 500 nM and is an antagonist of a7 nAChRs and a4ß2 and a3ß2 subunit-containing nAChRs in Xenopus oocytes expressing the human receptors (IC50s = 22, 2.9, and 0.45 µM, respectively); reduces global nerve action potential in isolated mouse sciatic nerves in a concentration-dependent manner; inhibits contraction in isolated mouse hemidiaphragm muscles (IC50 = 46 nM)
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