Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-(methoxy-d3)benzamide
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C14H19ClD3N3O2
Formula Weight: 302.81438
CAS Number: 1216522-89-2
Notes: Metoclopramide-d3 is intended for use as an internal standard for the quantification of metoclopramide (Item Nos. 39844 / 23360) by GC- or LC-MS. Metoclopramide is a dual antagonist of the serotonin (5-HT) receptor subtype 5-HT3 and dopamine D2 receptor (IC50s = 308 and 483 nM, respectively).{36216} It also reversibly inhibits acetylcholinesterase (AChE) isolated from human postmortem caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively).{36217} Oral administration of metoclopramide inhibits emesis induced by the DNA cross-linking agent cisplatin (Item No. 13119) in ferrets (ED50 = 6,170 µg/kg) and the dopamine receptor agonist apomorphine in dogs (ED50 = 0.45 mg/kg).{36215,36216} Metoclopramide also inhibits apomorphine-induced climbing and stereotypy in mice (ED50s = 2.2 and 6.5 mg/kg, respectively).{36219} Formulations containing metoclopramide have been used in the treatment of gastroesophageal reflux disease (GERD) and diabetic gastroparesis.
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