Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 5-methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
Purity: ≥98%
Formula Markup: C16H20N2O2S2
Formula Weight: 336.5
CAS Number: 1062271-24-2
Notes: MK6-83 is an activator of the transient receptor potential cation channel, mucolipin subfamily (TRPML1).{34609} TRPML1 is mutated in mucolipidosis type IV (MLIV), a hereditary lysosomal storage disorder characterized by severe delays in intellectual and motor development. MK6-83 increases activity of TRPML1 in lysosomes expressing either wild type or F465L-mutated channels (EC50s = 110 and 100 nM, respectively) and in MLIV patient-derived fibroblasts.{34609} It is more effective for F465L mutations than F408Δ (EC50 = 1,230 nM). It also improves zinc trafficking out of lysosomes in F408Δ-expressing fibroblast cells.
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