Notes: N-desmethyl Rosiglitazone is a major metabolite of rosiglitazone (Item Nos. 71740 / 71742 / 11884), a potent and selective PPARγ ligand present in formulations that have been used to treat type 2 diabetes.{8461,41078} Rosiglitazone is metabolized by the cytochrome P450 (CYP) isoform CYP2C8 to form N-desmethyl rosiglitazone.