NAADP (sodium salt)

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2'-(dihydrogen phosphate), adenosine 5'-(trihydrogen diphosphate), P'?5'-ester with 3-carboxy-1-ß-D-ribofuranosylpyridinium, inner salt, tetrasodium salt

Purity: ≥95%

Formula Markup: C21H23N6O18P3 / 4Na

Formula Weight: 832.317323

Notes: Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization.{47014,29682} It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then stimulates large-scale calcium release from granules and the endoplasmic reticulum mediated by type 1 ryanodine receptors (RyR2s), RyR3s, and inositol-(1,4,5)-triphosphate receptors (IP3Rs).{47014,47012} NAADP induces calcium mobilization in sea urchin and starfish eggs post fertilization to block polyspermy and activate embryogenesis.{47012} NAADP-induced calcium mobilization induces VEGF-mediated angiogenesis in human umbilical vein endothelial cells (HUVECs). It also alkalizes lysosomal pH thereby inhibiting fusion between autophagosomes and lysosomes and arresting autophagic flux in mouse embryonic stem cells.{47013}

• SKU: CAY25992-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 25992-5
• Package Unit: 5 mg
• Quantity Unit: STK