Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4-(2-methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol, monohydrochloride
Purity: ≥98%
Formula Markup: C24H28N2O3 / HCl
Formula Weight: 429.0
CAS Number: 1164469-60-6
Notes: Naftopidil is an α1-adrenergic receptor antagonist that competitively inhibits α-adrenoceptor-mediated contractions induced by noradrenaline with pA2 values of 6.73-8.15 in various blood vessels from dog, rabbit, guinea pig, and rat.{33266} It binds to the cloned human α1-adrenergic receptors with Ki values of 3.7, 20, and 1.2 nM for α1A, α1B and α1D, respectively.{33264} Clinical formulations of naftopidil are used in the treatment of benign prostatic hyperplasia in Japan.{33264} Naftopidil also exhibits antiproliferative activity, inhibiting the growth of androgen-sensitive LNcaP cells and androgen-insensitive PC-3 cancer cell lines with IC50 values of 22.2 and 33.2 µM, respectively.{33265}
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