Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (5a)-17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-morphinan-3,14-diol, monohydrochloride
Purity: ≥98%
Formula Markup: C21H25NO3 / HCl
Formula Weight: 375.9
CAS Number: 58895-64-0
Notes: A μ- and κ-opioid receptor antagonist (Kis = 0.91 and 1.03 nM, respectively, in CHO membranes expressing the human receptors); selective for μ- and κ-opioid receptors over δ-opioid receptors (Ki = 13.26 nM in CHO membranes expressing the human receptors); decreases self-administration of alcohol in non-alcohol- and alcohol-dependent rats; reduces food and water intake and body weight in obese and lean rats at 25 mg/kg per day; inhibits morphine-induced scratching behavior and increases in the latency to tail withdrawal in a warm water tail withdrawal assay in rhesus monkeys at 32 µg/kg
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