Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1,4-dihydro-2,6-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester
Purity: ≥98%
Formula Markup: C19H18F5NO4
Formula Weight: 419.3
CAS Number: 54280-71-6
Notes: Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome.{38802} It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells.{38803} It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.
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