Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one
Purity: ≥95%
Formula Markup: C24H25FN4O2
Formula Weight: 420.488403
CAS Number: 129029-23-8
Notes: An atypical antipsychotic; binds to dopamine D2, α1-adrenergic, and 5-HT2 receptors (Kis = 0.75, 0.46, and 0.14 nM, respectively); selective for these receptors over a panel of 26 additional receptors, transporters, channels, and enzymes but does bind to α2-ARs, 5-HT1A, 5-HT1D, and the histamine H1 receptor (Kis = 5.4, 6.8, 9.6, and 1.6 nM, respectively); inhibits apomorphine-induced stereotypy and cocaine- or amphetamine-induced agitation (ED50s = 0.018, 0.042, and 0.014 mg/kg, respectively) and tryptamine-induced clonic seizures and mescaline-induced head twitches (ED50s = 0.021 and 0.037 mg/kg, respectively) in rats; decreases locomotor activity and food intake (ED50s = 0.024 and 0.074 mg/kg, respectively) and induces catalepsy, palpebral ptosis, and hypotonia (ED50s = 0.39, 1.34, and 5.37 mg/kg, respectively) in rats; inhibits LSD-induced drug discrimination, ovalbumin and histamine-induced skin sensitization, acetic acid-induced writhing, and xylazine-induced loss of the righting reflex in rats (ED50s = 0.021, 1.18, 1.34, and 5.37 mg/kg, respectively)
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