PAR2 (1-6) amide (human) (trifluoroacetate salt), CAS 2379569-17-0

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: L-seryl-L-leucyl-L-isoleucylglycyl-L-lysyl-L-valinamide, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C28H54N8O7 / XCF3COOH

Formula Weight: 614.77808

CAS Number: 2379569-17-0

Notes: PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.{61701} It binds to NCTC 2544 cells expressing human PAR2 (Ki = 9.64 µM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50 = 0.075 µM).{61702} PAR2 (1-6) amide (100 µM) reduces colony formation of A549 lung cancer cells.{61701} It induces superoxide production and degranulation in isolated human eosinophils when used at a concentration of 500 µM.{50355} PAR2 (1-6) amide (5 µmol/kg) induces tear secretion in rats when used in combination with amastatin (Item No. 16719).{61703}

• SKU: CAY35204-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35204-25
• Package Unit: 25 mg
• Quantity Unit: STK