R-8507, CAS 338773-13-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1-(4-chlorophenyl)-4-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

Purity: ≥98%

Formula Markup: C16H8ClF3N4

Formula Weight: 348.7

CAS Number: 338773-13-0

Notes: R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI).{27910} It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 µM, respectively, in an ELISA using A549 lung epithelial cells. It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.

• SKU: CAY22479-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22479-25
• Package Unit: 25 mg
• Quantity Unit: STK