Shelf life (days): 730.0
Formulation: A crystalline solid
Formal Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-9-[(methylsulfonyl)oxy]-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid, methyl ester
Purity: ≥95%
Formula Markup: C22H28O9S
Formula Weight: 468.5
CAS Number: 862073-79-8
Notes: Salvinorin B mesylate (Mesyl Sal B) is a selective κ-opioid receptor agonist that is more potent than salvinorin A (Item No. 11487) in CHO cells transfected with the human κ-opioid receptor (EC50s = 30 and 40 nM, respectively).{34566,34288} It is a mesylated version of salvinorin B (Item No. 11488) and is highly selective for κ-opioid receptors over µ- and δ-opioid receptors.{34566} In vitro, it increases dopamine uptake via the dopamine transporter (DAT) in an ERK1/2-dependent manner but does not alter expression of DAT on the cell membrane.{34567} In rats, it increases the pain threshold and blocks reinstatement of cocaine drug-seeking.
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