Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (1a,2ß,4ß,5a,7ß)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol, monohydrochloride
Purity: ≥95%
Formula Markup: C8H13NO2 / HCl
Formula Weight: 191.655
CAS Number: 85700-55-6
Notes: Scopine is an active metabolite of the muscarinic acetylcholine receptor (mAChR) antagonist scopolamine (Item No. 40307).{43932} Scopine binds to muscarinic acetylcholine receptors with an IC50 value of 3 µM and is selective for muscarinic acetylcholine receptors over nicotinic acetylcholine receptors (IC50 = >500 µM).{43933} It reduces hyperphagia induced by the antipsychotics loxapine (Item No. 20760) and chlorpromazine (Item No. 16129) in C. elegans without affecting basal feeding.{43934} When conjugated to chlorambucil, scopine improves the blood-brain barrier permeability of chlorambucil (Item No. 23744).{43935}
English
Deutsch
