Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indole-1-acetic acid, monosodium salt
Purity: ≥98%
Formula Markup: C21H16FN2O2 / Na
Formula Weight: 370.359172
CAS Number: 950688-14-9
Notes: A DP2 receptor antagonist (Ki = 0.013 µM); selective for DP2 over DP1, TP, EP1-4, FP, and IP (Kis = >10 µM for all); inhibits calcium mobilization induced by PGD2 in CHO cells expressing human DP2 (IC50 = 0.028 µM); inhibits PGD2-induced Th2 T helper cell chemotaxis, IL-13 production, and apoptosis (IC50s = 0.028, 0.019, and 0.035 µM, respectively); reduces PGD2-induced blood eosinophilia in rats (ED50 = 0.04 mg/kg) and pulmonary eosinophil accumulation in guinea pigs (ED50 = 0.01 mg/kg); reduces Aβ plaque area and hippocampal microglial accumulation and improves learning and memory deficits in the TgF344 transgenic rat model of age-dependent and progressive Alzheimer’s disease
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