Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[[2S-methoxy-5-[5-(trifluoromethyl)-1H-tetrazol-1-yl]phenyl]methyl]-2-phenyl-3S-piperidinamine
Purity: ≥95%
Formula Markup: C21H23F3N6O
Formula Weight: 432.4
CAS Number: 168266-90-8
Notes: An NK1 receptor antagonist (Ki = 0.03 nM); selective for NK1 over NK2 and NK3 receptors (IC50s = >10,000 nM for both), 5-HT1A, 5-HT1D, and 5-HT2A receptors (Kis = 501, 251, and 316 nM, respectively), and histamine H1 and H2 receptors (Kis = 316 and 251 nM, respectively); inhibits resiniferatoxin-induced systemic vascular leakage in guinea pigs (ID50 = 0.007 mg/kg); inhibits emetogen-induced retching and vomiting in ferrets at 0.1 mg/kg; increases the number of entries into the open arms of the elevated plus maze in gerbils at 0.3-5 mg/kg and increases the percentage of time spent in the open arms at 5 mg/kg; potentiates citalopram-induced antidepressant-like behavior in the forced swim test in mice at 40 mg/kg but inhibits citalopram-induced anxiety-like behavior in rats and gerbils at 0.63 and 10 mg/kg
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