Shelf life (days): 1460.0
Formulation: A lyophilized powder
Formal Name: L-cysteinyl-L-lysylglycyl-L-lysylglycyl-L-alanyl-L-lysyl-L-cysteinyl-L-seryl-L-arginyl-L-leucyl-L-methionyl-L-tyrosyl-L-a-aspartyl-L-cysteinyl-L-cysteinyl-L-threonylglycyl-L-seryl-L-cysteinyl-L-arginyl-L-serylglycyl-L-lysyl-L-cysteinamide, cyclic (1?16),(8?20),(15?25)-tris(disulfide), trifluoroacetate salt
Purity: ≥95%
Formula Markup: C102H172N36O32S7 / XCF3COOH
Formula Weight: 2639.14252
CAS Number: 1660960-77-9
Notes: Ziconotide is a synthetic version of ω-conopeptide MVIIA, a peptide toxin originally found in the venom of the fish-eating marine snail C. magus, that blocks N-type calcium channels in rat brain membranes (Kds = 1.1-18 pM; IC50s = 2-55 pM).{37354},{37355} It blocks high-voltage-activated calcium currents in rat superior cervical ganglion neurons (IC50 = 32 nM) as well as depolarization-induced norepinephrine release by rat peripheral sympathetic efferent neurons and in rat hippocampus (IC50s = 1.2 and 5.5 nM, respectively).{37354} Intrathecal administration of ziconotide inhibits formalin-induced flinch responses and increases the paw withdrawal threshold in the paw pressure test in rats (ED50s = 0.11 and 0.60 μg, respectively), indicating antinociceptive effects.{37356} It decreases latency to tail withdrawal in a hot plate test in a rat model of sciatic chronic constriction injury.{37354} Ziconotide also reduces infarct volume post ischemia in a rat model of transient focal ischemia.{37357}
English
Deutsch
